There is something undeniably satisfying about a rich, creamy bowl of pasta. When you add bold Southwest flavors to the mix, it takes the dish to a whole new level. This Southwest Chicken Alfredo is a perfect fusion of creamy Alfredo sauce and the smoky, slightly spicy flavors of the Southwest. The best part? It is easy enough for beginner cooks to master, making it a fantastic choice for a quick and comforting dinner.

If you are someone who loves classic Alfredo but enjoys a bit of heat and complexity in your meals, this dish is for you. With tender, well-seasoned chicken, velvety cheese sauce, and a perfect balance of flavors, you will find yourself making this recipe over and over again.

Southwest Chicken Alfredo

Why This Recipe is Special

This Southwest Chicken Alfredo is more than just another pasta dish. Here’s why it stands out:

  • Beginner-Friendly: This recipe uses simple, everyday ingredients and easy cooking techniques, making it perfect for anyone just starting their cooking journey.
  • Bold Flavors: A mix of chili powder, cumin, and paprika gives the dish a warm, slightly smoky depth that pairs beautifully with the creamy sauce.
  • One-Pan Efficiency: Other than boiling the pasta, everything comes together in one skillet, cutting down on cleanup time.
  • Customizable: You can easily swap ingredients based on what you have on hand, making it a flexible and adaptable recipe.

Ingredients and Preparation

Each ingredient in this dish plays an essential role in building flavor, texture, and balance. Here’s a breakdown of the key components:

  • Chicken Breasts: These provide a lean and protein-packed base for the dish. You can also use boneless, skinless chicken thighs for a juicier alternative.
  • Penne Pasta: The perfect pasta choice for catching the creamy sauce in every bite. You can substitute with rotini, farfalle, or ziti.
  • Diced Tomatoes: Adds acidity and a touch of sweetness, helping to balance the richness of the sauce.
  • Heavy Cream: The foundation of the Alfredo sauce, giving it a rich and silky texture. For a lighter option, use half-and-half or a combination of milk and cream cheese.
  • Cheddar Cheese: Enhances the creaminess while adding a sharp, bold flavor. A Mexican cheese blend or Monterey Jack are great alternatives.
  • Onion & Garlic: Essential aromatics that bring depth and savoriness to the dish.
  • Honey: A surprising ingredient that subtly balances the spice, creating a well-rounded flavor.
  • Olive Oil & Butter: Used to cook the chicken and create a flavorful base for the sauce.
  • Fresh Cilantro: Adds a burst of freshness at the end. If you’re not a fan, try chopped parsley or green onions.
  • Southwest Seasoning Blend: A mix of chili powder, cumin, oregano, paprika, black pepper, salt, and a touch of cayenne for a smoky, spicy kick.

Step-by-Step Instructions

Step 1: Prepare the Seasoning Blend
In a small bowl, mix together chili powder, cumin, oregano, paprika, black pepper, salt, and cayenne. This blend is the key to the bold Southwest flavor of the dish.

Step 2: Season the Chicken
Cut the chicken into strips and place them in a bowl. Drizzle with honey and half of the seasoning blend, tossing until fully coated. Let it sit for a few minutes to absorb the flavors.

Step 3: Cook the Pasta
Bring a large pot of salted water to a boil and cook the penne pasta according to the package instructions until al dente. Drain and set aside.

Step 4: Sear the Chicken
Heat olive oil in a large skillet over medium heat. Once hot, add the seasoned chicken and cook for a few minutes on each side until golden brown and fully cooked. Transfer the chicken to a plate and set aside.

Step 5: Sauté the Aromatics
In the same skillet, melt the butter and add the chopped onion. Cook until softened, then add the minced garlic and cook for another minute until fragrant.

Step 6: Build the Sauce
Add the diced tomatoes and the remaining seasoning blend to the skillet. Stir well and bring to a low simmer. Slowly pour in the heavy cream while stirring continuously until fully incorporated. Allow the mixture to gently simmer.

Step 7: Combine Everything
Return the cooked chicken to the skillet and stir in the shredded cheddar cheese, allowing it to melt into the sauce. Add the drained pasta and toss everything together until well coated. Remove from heat and let it sit for a few minutes to allow the flavors to meld.

Step 8: Garnish and Serve
Before serving, sprinkle fresh chopped cilantro over the pasta for a final burst of freshness. Enjoy immediately!

Southwest Chicken Alfredo (1)

Beginner Tips and Notes

Cooking for the first time? Here are a few extra tips to ensure success:

  • How to Know When Chicken is Cooked: Use a meat thermometer—chicken is done when it reaches an internal temperature of 165°F (75°C). If you don’t have one, cut into the thickest piece—there should be no pink inside.
  • Adjusting Spice Levels: If you prefer a milder dish, reduce the cayenne pepper or omit it entirely. For extra heat, add a pinch of red pepper flakes.
  • Thicker or Thinner Sauce: If the sauce is too thick, add a splash of milk or reserved pasta water. If too thin, let it simmer a bit longer until it thickens naturally.
  • Prepping Ahead: You can season the chicken and chop the ingredients ahead of time to make the cooking process even smoother.

Serving Suggestions

This pasta is a hearty meal on its own, but you can elevate the dish with these accompaniments:

  • Garlic Bread: A crispy, buttery side that pairs beautifully with the creamy sauce. Try homemade garlic bread or Texas toast.
  • Side Salad: A fresh green salad with a zesty dressing balances the richness of the dish.
  • Roasted Vegetables: Roasted bell peppers, zucchini, or asparagus make excellent sides.

Storage Tips

  • Store any leftovers in an airtight container in the refrigerator for up to 2-3 days.
  • Reheat gently on the stove over low heat, adding a splash of milk or cream to loosen the sauce. You can also microwave it in short intervals, stirring between each one.
  • This dish is not ideal for freezing due to the dairy-based sauce, which can separate when thawed.

Conclusion: Try This Easy Southwest Chicken Alfredo Tonight

If you love bold flavors, creamy sauces, and quick meals, this Southwest Chicken Alfredo is the perfect recipe for you. It is simple enough for beginners yet impressive enough for a family dinner or casual gathering. Try it tonight and let us know how it turns out in the comments. Happy cooking!

FAQ About Southwest Chicken Alfredo

Can I use a different type of pasta?

Yes! While penne is ideal for holding the creamy sauce, you can substitute it with rotini, farfalle, ziti, or even fettuccine if desired.

Is this dish very spicy?

This recipe has a mild heat from the cayenne pepper and chili powder, but you can easily adjust the spice level by reducing or omitting the cayenne. For more heat, add crushed red pepper flakes or diced jalapeños.

Can I make this recipe ahead of time?

Yes, you can cook the chicken and sauce in advance and store them separately in the fridge for up to 2 days. When ready to serve, reheat gently and toss with freshly cooked pasta.

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Southwest Chicken Alfredo

Southwest Alfredo Penne Pasta


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  • Author: Kathryne Taylor
  • Total Time: 30 minutes
  • Yield: 4 servings 1x

Description

This Southwest Chicken Alfredo is a creamy, cheesy pasta dish infused with smoky, bold flavors from a homemade Southwest seasoning blend. Tender pan-seared chicken is paired with a rich and velvety Alfredo-style sauce, creating the perfect balance of spice and creaminess. This easy one-pan meal is perfect for a weeknight dinner and is sure to be a hit with the whole family!


Ingredients

Scale
  • 1 lb. chicken breasts, cut into 1-inch strips
  • ½ lb. penne pasta
  • 1 (15 oz.) can diced tomatoes, drained
  • 1 cup heavy cream
  • 1 ½ cups shredded cheddar cheese
  • 1 cup chopped onion
  • 4 garlic cloves, minced
  • 1 tablespoon honey
  • 1 tablespoon olive oil
  • 1 tablespoon butter
  • 2 tablespoons chopped cilantro
  • Southwest Seasoning Blend:
  • 1 ½ teaspoons chili powder
  • ½ teaspoon cumin
  • ½ teaspoon oregano
  • 1 teaspoon paprika
  • ¼ teaspoon black pepper
  • ½ teaspoon salt
  • ⅛ teaspoon cayenne

Instructions

  1. Prepare the Seasoning: In a small bowl, mix chili powder, cumin, oregano, paprika, black pepper, salt, and cayenne. This seasoning blend will give the dish its signature Southwest flavor.
  2. Season the Chicken: Place the sliced chicken breasts in a bowl and drizzle with honey. Sprinkle half of the prepared seasoning blend over the chicken, tossing until fully coated. Let it sit while preparing the other ingredients to enhance flavor absorption.
  3. Cook the Pasta: Bring a large pot of salted water to a boil. Add penne pasta and cook according to package directions until al dente. Drain and set aside, reserving about ½ cup of pasta water in case the sauce needs thinning.
  4. Sear the Chicken: Heat olive oil in a large skillet over medium heat. Once hot, add the seasoned chicken pieces in a single layer. Cook for about 3-4 minutes on each side, or until golden brown and cooked through. The internal temperature should reach 165°F. Remove the chicken from the skillet and set aside.
  5. Sauté the Aromatics: In the same skillet, melt butter and add the chopped onion. Sauté for about 2-3 minutes until softened. Stir in the minced garlic and cook for an additional minute until fragrant.
  6. Create the Sauce: Pour the diced tomatoes and the remaining Southwest seasoning into the skillet. Stir well and bring to a gentle simmer. Slowly add the heavy cream while stirring continuously until fully incorporated. Let the sauce simmer for a couple of minutes until slightly thickened.
  7. Combine Everything: Return the cooked chicken to the skillet, stirring to coat in the sauce. Sprinkle in the shredded cheddar cheese and stir until melted and fully blended. Add the drained pasta and toss everything together until well coated. If the sauce seems too thick, add a small amount of reserved pasta water to reach your desired consistency.
  8. Garnish and Serve: Remove from heat and let the pasta sit for a couple of minutes to allow flavors to meld. Sprinkle with fresh chopped cilantro before serving. Enjoy warm!

Notes

  • If you prefer a milder version, omit the cayenne or reduce the amount of chili powder.
  • For extra creaminess, stir in a little cream cheese or additional cheddar cheese.
  • Store leftovers in an airtight container in the refrigerator for up to 3 days. Reheat gently over low heat, adding a splash of milk or cream to loosen the sauce.
  • Prep Time: 5 minutes
  • Cook Time: 25 minutes
  • Category: Main Course
  • Method: Stovetop
  • Cuisine: American-Southwest

Nutrition

  • Serving Size: 1 generous portion
  • Calories: 1092 kcal
  • Sugar: 49g
  • Sodium: 25g
  • Fat: 48g
  • Saturated Fat: 25g
  • Unsaturated Fat: 17g
  • Trans Fat: 0.1g
  • Carbohydrates: 121g
  • Fiber: 20g
  • Protein: 57g
  • Cholesterol: 190mg

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